Infarcted canine ventricular myocytes exhibit reduced amplitudes and altered kinetics of delayed rectifier K currents, which may impact repolarization dynamics.
The decrease in I(Kr) and I(Ks) amplitudes and changes in their kinetics in infarcted tissue might be due to a decrease in functional channels and/or changes in their subunit composition. Heterogeneous changes in I(Kr) and I(Ks) in infarcted hearts may impact on the effects of varying heart rate or neurohumoral modulation on repolarization.
Min Jiang (Sun,) studied this question.