Left atrial levels of tPA, plasmin, PAI-I, antiplasmin, PF4, and vWF significantly exceeded corresponding peripheral venous levels in patients with mitral stenosis (P < 0.05).
Observational (n=46)
Are regional left atrial coagulation, fibrinolytic, and platelet activation markers increased compared to peripheral venous levels in patients with mitral stenosis?
Patients with mitral stenosis exhibit increased regional left atrial coagulation, fibrinolytic activity, and platelet activation compared to systemic levels, which may contribute to the pathophysiology of left atrial thrombus formation.
p-value: p=<0.05
Systemic thromboembolism is a major complication of mitral stenosis (MS), especially in those patients having atrial fibrillation (AF). Recent evidence has suggested that regional left atrial coagulation activity may be increased in MS and may contribute to the pathophysiology of left atrial thrombus. However, the relation of left atrial coagulation activity to factors that predispose to left atrial thrombus formation is unknown. Also, the relations between left atrial and systemic coagulation activity, fibrinolysis, and platelet activation remain unresolved. Left atrial and peripheral venous levels of fibrinogen, antithrombin III, factor VII and factor VIII for coagulation, D-dimer, tPA and PAI-I, plasmin and antiplasmin for fibrinolysis, and platelet factor 4 and vWF for platelet activation, and endothelial dysfunction were measured in 46 patients with MS and normal clotting times who were undergoing percutaneous mitral valvuloplasty. Left atrial tPA, plasmin, PAI-I, antiplasmin, PF4, and vWF levels exceeded the corresponding peripheral venous levels (P 0.05). The results suggest that there are significant variations in the indices of coagulation, fibrinolytic system and platelet activation, and endothelial dysfunction between left atrial and peripheral venous blood samples of patients with MS that may be due to limited spillover from the left atrium to the systemic circulation.
Boyacı et al. (Thu,) conducted a observational in Mitral stenosis (n=46). Left atrial blood sampling vs. Peripheral venous blood sampling was evaluated on Levels of coagulation, fibrinolysis, and platelet activation markers (p=<0.05). Left atrial levels of tPA, plasmin, PAI-I, antiplasmin, PF4, and vWF significantly exceeded corresponding peripheral venous levels in patients with mitral stenosis (P < 0.05).