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CNS 7065 is a high-affinity and selective ligand for the benzodiazepine site on the GABAA receptor. CNS 7056 does not show selectivity between GABAA receptor subtypes. CNS 7056 is a potent sedative in rodents with a short duration of action. Inhibition of substantia nigra pars reticulata firing and the inhibition of the effects of CNS 7056 by flumazenil show that it acts at the brain benzodiazepine receptor.
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Gavin J. Kilpatrick
Margaret McIntyre
Richard F. Cox
Anesthesiology
Northeastern University
Research Triangle Park Foundation
Takeda (United States)
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Kilpatrick et al. (Wed,) studied this question.
synapsesocial.com/papers/69d773ea9c65a8c80448f449 — DOI: https://doi.org/10.1097/01.anes.0000267503.85085.c0