The BLOCK HF trial is designed to enroll up to 1,636 patients to determine whether biventricular pacing is superior to right ventricular pacing in patients with AV block and LV dysfunction.
RCT (n=1,636)
Double-blind
Randomized
Yes
BACKGROUND: Right ventricular (RV) pacing restores ventricular systole in patients with atrioventricular (AV) block, yet recent studies have suggested that in patients with AV block and left ventricular (LV) dysfunction, RV pacing may exacerbate the progression to heart failure (HF). BLOCK HF is a prospective, multi-center, randomized, double-blind, controlled trial designed to determine whether patients with AV block, LV dysfunction (EF or = 15% increase in left ventricular end systolic volume index LVESVI) for patients with BiV pacing is superior to that of patients with RV pacing. METHODS: Patients with AV block and LV dysfunction who require permanent pacing and undergo successful implantation of a commercial Medtronic CRT device, with or without an ICD, will be randomized to BiV or RV pacing. Patients are followed at least every 6 months until study closure. Up to 1,636 patients may be enrolled in 150 centers worldwide. CONCLUSION: BLOCK HF is a large, randomized, clinical study in pacing-indicated patients with AV block, mild to moderate HF symptoms, and LV dysfunction to determine whether BiV pacing is superior to RV pacing in slowing the progression of HF.
Curtis et al. (Fri,) conducted a rct in Atrioventricular block and left ventricular dysfunction (n=1,636). Biventricular (BiV) pacing vs. Right ventricular (RV) pacing was evaluated on Time to first event (all-cause mortality, heart failure-related urgent care, or a >= 15% increase in left ventricular end systolic volume index [LVESVI]). The BLOCK HF trial is designed to enroll up to 1,636 patients to determine whether biventricular pacing is superior to right ventricular pacing in patients with AV block and LV dysfunction.