What does this research mean for the field?

Quantitative textural features (RLNU and GLNU) on MRI are significantly elevated in hypertrophic segments compared to non-hypertrophic segments in HCM patients, and in non-hypertrophic HCM segments compared to healthy controls. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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January 1, 2014Open Access

Quantitative texture features as objective metrics of enhancement heterogeneity in hypertrophic cardiomyopathy

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Hypertrophic cardiomyopathy (n=16). Intervention: Late gadolinium enhanced MRI with quantitative texture feature analysis vs. Healthy volunteers. Primary outcome: Differences in run-length non-uniformity (RLNU) and grey-level non-uniformity (GLNU) among segment groups (p=<0.0001).

Key Result

Quantitative textural features (RLNU and GLNU) were significantly elevated in hypertrophic segments compared to non-hypertrophic segments, and in non-hypertrophic HCM segments versus healthy controls.

Study Design

Type

Observational (n=16)

Multicenter

Structured PICO

Do quantitative texture features on LGE MRI differentiate hypertrophied and non-hypertrophied segments in HCM patients from healthy volunteers?

Population

12 patients with hypertrophic cardiomyopathy (HCM) and 4 healthy volunteers

Intervention

Quantitative texture analysis (run-length non-uniformity [RLNU] and grey-level non-uniformity [GLNU]) of Late Gadolinium Enhanced (LGE) MRI

Comparator

Healthy volunteers and non-hypertrophied/non-fibrotic segments

Outcome

Differences in RLNU and GLNU among segment groups (Hypertrophic/Fibrotic [H+/F+], Hypertrophic/Non-Fibrotic [H+/F-], Non-hypertrophic/Fibrotic [H-/F+], Non-hypertrophic/Non-Fibrotic [H-/F-], and healthy)surrogate

Quantitative textural features (RLNU and GLNU) on LGE MRI can objectively differentiate HCM segments from healthy myocardium, even in non-hypertrophic and non-fibrotic regions, suggesting potential as markers for incipient cardiomyopathic changes.

Main Result

p-value: p=<0.0001

Limitations

Pending further validation

Abstract

Background Hypertrophic cardiomyopathy (HCM) results in myocardial disarray, hypertrophy and fibrosis. Late gadolinium enhanced MRI (LGE) can assess the presence and extent of fibrosis, which is associated with the development of arrhythmias and sudden cardiac death. However, enhancement may not always be present or only sparsely distributed. Thus, one of the challenges is how best to describe heterogeneous LGE patterns in an objective fashion that informs clinical decision making. Quantitative texture features may provide clinicians with an objective means of describing the heterogeneity of LGE patterns in HCM. We hypothesized that hypertrophied segments would exhibit greater grey-level heterogeneity than both (a) non-hypertrophied segments in HCM patients, and (b) healthy volunteers.

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Cite This Study

Thornhill et al. (Wed,) conducted a observational in Hypertrophic cardiomyopathy (n=16). Late gadolinium enhanced MRI with quantitative texture feature analysis vs. Healthy volunteers was evaluated on Differences in run-length non-uniformity (RLNU) and grey-level non-uniformity (GLNU) among segment groups (p=<0.0001). Quantitative textural features (RLNU and GLNU) were significantly elevated in hypertrophic segments compared to non-hypertrophic segments, and in non-hypertrophic HCM segments versus healthy controls.

synapsesocial.com/papers/6a16e01c66334ab13b056d7d https://doi.org/https://doi.org/10.1186/1532-429x-16-s1-p351

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