Acquired adiponectin deficiency, rather than obesity per se, was an independent correlate of endothelial dysfunction in young adult monozygotic twins discordant for obesity.
Observational (n=36)
Is acquired obesity associated with endothelial dysfunction independent of genetic influences in young adult monozygotic twins?
In young adults, acquired adiponectin deficiency rather than obesity itself is independently associated with endothelial dysfunction when controlling for genetic factors.
OBJECTIVE: To determine whether acquired obesity or accompanying metabolic changes such as adiponectin deficiency, insulin resistance, dyslipidemia, or visceral fat are associated, independent of genetic influences, with endothelial dysfunction by studying young adult monozygotic (MZ) twin pairs discordant for obesity. RESEARCH METHODS AND PROCEDURES: Nine obesity-discordant (intra-pair difference in BMI, 3.8 to 10.1 kg/m(2)) and nine concordant (0 to 2.3 kg/m(2)) 24- to 27-year-old MZ twin pairs were identified from a population-based FinnTwin16-sample. Endothelial function was measured by blood flow responses to intrabrachial infusions of an endothelium-dependent (acetylcholine) and an endothelium-independent (sodium nitroprusside) vasodilator. Whole body insulin sensitivity was measured using the euglycemic insulin clamp technique, and forearm and body composition were measured with magnetic resonance imaging and DXA. In addition, serum levels of adiponectin, high-sensitivity C-reactive protein, and lipids were determined. RESULTS: The heavier co-twins of the discordant pairs had significantly lower whole body insulin sensitivity than the leaner co-twins. Blood flows/muscle volume during infusions of acetylcholine and sodium nitroprusside were not altered by obesity. However, intra-pair differences in serum adiponectin, intra-abdominal fat, and C-reactive protein were significantly correlated with those in endothelial function. Only the relationship between intra-pair differences in adiponectin and endothelial function persisted in multiple linear regression analysis. Obesity-concordant co-twins had comparable insulin sensitivity and endothelial function. DISCUSSION: In young adult MZ twins discordant for obesity, acquired adiponectin deficiency rather than obesity per se is an independent correlate of endothelial dysfunction.
Pietiläinen et al. (Mon,) conducted a observational in Obesity and Endothelial Dysfunction (n=36). Acquired obesity (heavier co-twin) vs. Leaner co-twin was evaluated on Endothelial function (blood flow responses to acetylcholine and sodium nitroprusside). Acquired adiponectin deficiency, rather than obesity per se, was an independent correlate of endothelial dysfunction in young adult monozygotic twins discordant for obesity.
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