Atrioventricular pressure half-time varied inversely with mitral valve orifice area, measuring approximately 100 msec in mild, 200 msec in moderate, and ≥300 msec in severe mitral stenosis.
Observational (n=20)
Does diastolic left atrioventricular pressure half-time correlate with the anatomic severity of mitral stenosis?
Atrioventricular pressure half-time provides a reliable, exercise-independent hemodynamic measure of mitral stenosis severity that varies inversely with anatomic orifice area.
In 20 patients studied by cardiac catheterization, the time required for the diastolic left atrioventricular pressure difference to fall to half its initial value (half-time) varied with the anatomic severity of the valvular stenosis. In mild mitral stenosis, the half-time was approximately 100 msec; in moderate stenosis, it was about 200 msec; and it was 300 msec or longer in severe stenosis. The half-time at the nonstenotic mitral valve was less than 25 msec. Although exercise increased the atrioventricular pressure gradient, heart rate, and cardiac output significantly, the half-time was affected only slightly. Mitral regurgitation of various severities did not affect the half-time. The half-time appears to vary inversely with the anatomic orifice area of the mitral valve. The determination of the half-time obviates the need for the commonly used exercise test for the evaluation of mitral stenosis.
Libanoff et al. (Mon,) conducted a observational in Mitral stenosis (n=20). Atrioventricular pressure half-time measurement was evaluated on Atrioventricular pressure half-time. Atrioventricular pressure half-time varied inversely with mitral valve orifice area, measuring approximately 100 msec in mild, 200 msec in moderate, and ≥300 msec in severe mitral stenosis.
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