Does fosinopril reduce ambulatory blood pressure more effectively than isradipine in outpatients with mild to moderate primary systemic hypertension?
Fosinopril 20 mg once daily is significantly more effective than isradipine 5 mg once daily in reducing systolic blood pressure load in patients with mild to moderate hypertension.
Abstract We compared the efficacy and tolerability of is‐radipine (ISR) and fosinopril (FOS) once‐a‐day administration in 17 outpatients, 9 men and 8 women, aged 35–65 years (mean ± SD= 58 ± 10 years), affected by mild to moderate primary systemic hypertension. The patients were given single‐blind placebo for 2 weeks and thereafter, in double‐blind, randomized, crossover sequence, ISR (5 mg) and FOS (20 mg), both for 4 weeks. At the end of each period, patients underwent 24‐h noninvasive blood pressure (BP) monitoring by means of an A however, FOS proved to be significantly more effective than ISR.
Perticone et al. (Sat,) studied this question.