Radiofrequency catheter ablation of cardiac fat pads significantly attenuated the veratridine-induced decrease in heart rate compared to control (22.9 ± 8.5 bpm vs 93.3 ± 18.4 bpm, P<0.01).
Does epicardial radiofrequency catheter ablation of cardiac fat pads attenuate the veratridine-induced Bezold-Jarisch reflex in dogs?
RFCA of cardiac fat pads attenuates the cardio-vagal component of the Bezold-Jarisch reflex in dogs, suggesting potential therapeutic implications for cardio-inhibitory vasovagal syncope.
Absolute Event Rate: 22.9% vs 93.3%
p-value: p=<0.01
BACKGROUND: Bezold-Jarisch reflex (BJR) plays an important role in the pathophysiology of several cardiovascular disorders. Radiofrequency catheter ablation (RFCA) of the vagal ganglia in cardiac fat pads (FPs) may attenuate BJR. The purpose of this study was to examine the effects of RFCA of the cardiac FPs on veratridine-induced BJR in dogs. METHODS AND RESULTS: This study was performed in 30 pentobarbital-anesthetized and open-chest dogs: control group received no ablation (n = 15); and ablation group (n = 15) received epicardial ablation of the 3 FPs located near the right pulmonary vein, the inferior vena cava, and the aortic root. The BJR was induced by injection of veratridine (15 μg/kg) into the left ventricle. Before injection of veratridine, there were no significant differences in heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), left ventricular systolic pressure (LVSP), left ventricle end-diastolic pressure (LVEDP), left ventricular peak systolic and diastolic velocity (±dp/dt(max)) between these 2 groups (P > 0.05). However, the veratridine-induced decrease of HR in ablation group was significantly lower than that in control group (22.9 ± 8.5 bpm vs 93.3 ± 18.4 bpm, P 0.05). CONCLUSIONS: RFCA of the cardiac FPs significantly attenuated veratridine-induced cardio-vagal component but not the vasodepressor component of the BJR. This might have therapeutic implications in BJR-related disorders such as cardio-inhibitory vasovagal syncope.
Xia et al. (Mon,) conducted a other in Bezold-Jarisch reflex (n=30). Radiofrequency catheter ablation (RFCA) of cardiac fat pads vs. No ablation was evaluated on Veratridine-induced decrease of heart rate (p=<0.01). Radiofrequency catheter ablation of cardiac fat pads significantly attenuated the veratridine-induced decrease in heart rate compared to control (22.9 ± 8.5 bpm vs 93.3 ± 18.4 bpm, P<0.01).