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SUMMARY A method for assaying cell-mediated cytotoxicity against cultured target cells in 10 µl of medium is described. The test possesses sufficient sensitivity to detect tumor-specific as well as histocompatibility antigens. Lymphoid cells from the peritoneal cavity, spleen, and peripheral blood exhibited strong cytotoxicity, while lymph node cells were less effective. Reduction of target cell survival was also observed with cells from mice receiving either single or multiple immunizations.
Takasugi et al. (Sun,) studied this question.