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Herein we report a novel targeted drug delivery system consisting of nanoparticle–aptamer bioconjugates, which can carry both hydrophobic and hydrophilic chemotherapeutic drugs simultaneously, and deliver them selectively in a targeted and temporally distinct manner. This work provides a robust platform for targeted co-delivery of chemotherapeutic agents with the hope of both leveraging the synergistic effects of multiple drugs and also potentially suppressing the likelihood of drug resistance by the treated tissues.
Zhang et al. (2007) studied this question.