A general biophysical model of the BOLD signal was developed as a look-up-table and verified against concurrent fMRI and optical imaging measurements of activation-induced hemodynamics.
A new general biophysical model of the BOLD signal was developed and verified, which may improve quantitative estimation of hemodynamic changes in fMRI.
The dependency of the blood oxygenation level dependent (BOLD) signal on underlying hemodynamics is not well understood. Building a forward biophysical model of this relationship is important for the quantitative estimation of the hemodynamic changes and neural activity underlying functional magnetic resonance imaging (fMRI) signals. We have developed a general model of the BOLD signal which can model both intra- and extravascular signals for an arbitrary tissue model across a wide range of imaging parameters. The model of the BOLD signal was instantiated as a look-up-table (LuT), and was verified against concurrent fMRI and optical imaging measurements of activation induced hemodynamics.
Martindale et al. (Fri,) conducted a other in fMRI BOLD signal modeling. General model of the BOLD signal (look-up-table) was evaluated on Verification against concurrent fMRI and optical imaging measurements. A general biophysical model of the BOLD signal was developed as a look-up-table and verified against concurrent fMRI and optical imaging measurements of activation-induced hemodynamics.