Does intraoperative dexmedetomidine infusion reduce anesthetic requirement and improve recovery from anesthesia compared to oral clonidine premedication in patients undergoing major spine surgery?
Patients undergoing major spine surgery
Intraoperative dexmedetomidine infusion
Oral clonidine premedication
Anesthetic requirement and recovery from anesthesia
Intraoperative dexmedetomidine infusion provides a greater anesthetic-sparing effect than oral clonidine premedication in major spine surgery, with similar recovery and hemodynamic profiles.
Both clonidine and dexmedetomidine have anesthetic-sparing effect; however, it was more with dexmedetomidine than with clonidine. Recovery from isoflurane anesthesia was similar between both groups. Both are equally effective in controlling the hemodynamic response and reducing the blood loss during spine surgery.
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Mariappan et al. (Thu,) studied this question.
synapsesocial.com/papers/69df3e8435659245ec6144a7 — DOI: https://doi.org/10.1097/ana.0b013e3182a2166f
Ramamani Mariappan
Christian Medical College, Vellore
Harinarayanaprabhu Ashokkumar
Balaji Kuppuswamy
Christian Medical College, Vellore
Journal of Neurosurgical Anesthesiology
Christian Medical College, Vellore
Christian Medical College
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