Heterogeneous Catalysts for the One-Pot Synthesis of Chemicals and Fine Chemicals

EN It is apparent that intensi¿cation in chemical and most ¿cally in catalytic processes is of growing in interest researchers. This is not only because of the potential impact if translated into industrial application, 24. One-Pot r, r-Dialkylation of Nitriles using Metal/HTsa conditions: Method A: (i) nitrile (1 mmol) carbonyl compounds (1 mmol), Pd/HT (0. 1 g; Pd 0. 01 mmol), toluene (3 mL), 2 h, 80 °C,. After completion of the aldol reaction, the reaction mixture was further treated at 60 °C for 1 h under H2 (1 atm). (ii) Ole¿n (1. 5 mmol), 5 h, 70 °C, Ar. Method B: (i) nitrile (1 mmol), alcohol (2 mL), Ru/HT (0. 15 g; 0. 0075 mmol), 180 °C, 20 h, Ar. (ii) Ole¿n (3 mmol), DMSO (2 mL), 150 °C, 1 h, Ar. bOverall yield based on nitrile. cAt 110 °C, 12 h for Michael addition. dA solution of methyl vinyl ketone (1. 5 mmol) in toluene (2 mL) was slowly added over 6 h and further reacted for 4 h. eDMF (3 mL) was used as solvent. fDMF (3 mL) was used as solvent for Michael. gDetermined by GC by an internal standart. 155. Sequential Acetal Hydrolysis Followed by Condensation and Subsequent Hydrogenation 156. Sequential Acetal Hydrolysis Followed by Type Condensations Catalysts for One-Pot Synthesis Chemical Reviews, 2011, Vol. 111, No. 2 1127but also because it is challenging and attractive to achieve molecular design of a catalyst that allows cascade type to be performed.