High-resolution 3D LGE cardiac MR yielded higher scar signal-to-noise ratio (P<0.001) and comparable scar volumes to 2D LGE (13.2 vs 14.5 mL, P=0.59) in patients with prior myocardial infarction.
Cross-Sectional (n=14)
Does high spatial resolution 3D LGE cardiac MR improve image quality and scar quantification compared to conventional 2D LGE in patients with prior myocardial infarction?
High-resolution 3D LGE cardiac MR provides superior image sharpness and SNR compared to conventional 2D LGE, allowing for more confident identification of papillary muscle scar while maintaining agreement in total scar volume.
Effect estimate: R = 0.91
Absolute Event Rate: 13.2% vs 14.5%
p-value: p=0.59
PURPOSE: To compare higher spatial resolution 3D late gadolinium enhancement (LGE) cardiovascular magnetic resonance (Cardiac MR) with 2D LGE in patients with prior myocardial infarction. MATERIALS AND METHODS: Fourteen patients were studied using high spatial resolution 3D LGE (1.3 x 1.3 x 5.0 mm(3)) and conventional 2D LGE (2 x 2 x 8 mm(3)) scans. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were measured. Total infarct volume, peri-infarct volume measured in a limited slab, and papillary muscle scar volume were compared using Bland-Altman analysis. Image quality was graded. RESULTS: 3D LGE had higher scar SNR (P < 0.001), higher myocardial SNR (P = 0.001), higher papillary scar-blood CNR (P = 0.01), and greater sharpness (P = 0.01). The scar volumes agreed (14.5 +/- 8.2 for 2D, vs. 13.2 +/- 8.8 for 3D), with bias +/- 2 standard deviations (SDs) of 0.5 +/- 6.8 mL, P = 0.59 R = 0.91. The peri-infarct volumes correlated but less strongly than scar (P = 0.40, R = 0.77). For patients with more heterogeneous scar, larger peri-infarct volumes were measured by 3D (1.9 +/- 1.1 mL for 2D vs. 2.4 +/- 1.6 mL for 3D, P = 0.15, in the matched region). Papillary scar, present in 6/14 (42%) patients, was more confidently identified on 3D LGE. CONCLUSION: Higher spatial resolution 3D LGE provides sharper images and higher SNR, but less myocardial nulling. Scar volumes agree well, with peri-infarct volumes correlating less well. 3D LGE may be superior in visualization of papillary muscle scar.
Peters et al. (Mon,) conducted a cross-sectional in Prior myocardial infarction (n=14). High spatial resolution 3D late gadolinium enhancement (LGE) cardiac MR vs. Conventional 2D LGE cardiac MR was evaluated on Total infarct (scar) volume (R = 0.91, p=0.59). High-resolution 3D LGE cardiac MR yielded higher scar signal-to-noise ratio (P<0.001) and comparable scar volumes to 2D LGE (13.2 vs 14.5 mL, P=0.59) in patients with prior myocardial infarction.