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THE SECRETION of sugar into the blood by the liver of the fasting animal 11 was demonstrated by the brilliant pioneer work of Claude Bernard (i). The inadequate chemical and physiological methods available to him and his contemporaries initiated an involved controversy which ultimately partly obscured his original conceptions (2). It remained for F. C. Mann (3), who devised the first practical method for complete hepatectomy in mammals, to finally establish the liver as the prime factor for the maintenance of the normal blood sugar level. The presence of appreciable quantities of glycogen in the muscles of their hepatectomized dogs during profound hypoglycemia, ledMann and his coworkers (4) to conclude that muscle glycogen is incapable of sufficiently rapid conversion to glucose to play a significant r6le in maintaining the blood sugar level.
Samuel Soskin (Thu,) studied this question.