Pathology of the Cardiac Conduction System in Amyloidosis

Article1 July 1966Pathology of the Cardiac Conduction System in AmyloidosisTHOMAS N. JAMES, M.D., F.A.C.P.THOMAS N. JAMES, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-1-28 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAmyloidosis often involves the heart, and experienced clinicians have learned to suspect this disease in any patient presenting with unexplained cardiac enlargement or cardiac failure. Atrial fibrillation and other arrhythmias as well as various degrees of heart block are frequent manifestations of cardiac amyloidosis (1-12). Examinations of the cardiac conduction system seldom have been reported in amyloidosis, however, and may be negative (13, 14). Since amyloid commonly deposits in the coronary arteries (12, 15), functional disturbances in cardiac rhythm and conduction might be due to ischemia in the critical conduction centers secondary to amyloid in the arteries. Similarly, since amyloid...References1. AMOSANDERSONPUFLETTEPPSKALOKERINOSFREEMANSTUCKEYTHOMASISBISTERROWEPAYNE BJDJRDRGJZDSIDJPWH: Clinical pathological conference. Amer. Heart J. 64: 255, 1962. CrossrefGoogle Scholar2. BERNREITER M: Cardiac amyloidosis. Electrocardiographic findings. Amer. J. Cardiol. 1: 644, 1958. CrossrefMedlineGoogle Scholar3. BOYDPARKINBROADBENTEDWARDS GKTWJCJE: Primary amyloidosis presenting with profound renal failure. Mayo Clinic Proc. 34: 177, 1959. MedlineGoogle Scholar4. ELIOTMCGEEBLOUNT RSHJSG: Cardiac amyloidosis. Circulation 23: 613, 1961. CrossrefGoogle Scholar5. FARROKHWALSHMASSIE ATJE: Amyloid heart disease. Amer. J. Cardiol. 13: 750, 1964. CrossrefMedlineGoogle Scholar6. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: THOMAS N. JAMES, M.D., F.A.C.P.Affiliations: Detroit, MichiganFrom the Section on Cardiovascular Research, Henry Ford Hospital, Detroit, Mich.This study was supported in part by grants from the Michigan Heart Association and grants H-5197 and H-7108 from the U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to Thomas N. James, M.D., Henry Ford Hospital, Detroit, Mich. 48202. 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A clinico-pathological correlation in 65 cases.Sudden death in babies: New observations in the heartA clinical analysis of the course and prognosis of forty-two patients with amyloidosisThe coronary circulation and conduction system in acute myocardial infarctionPathology of small coronary arteriesAmyloidosis 1 July 1966Volume 65, Issue 1Page: 28-36KeywordsAmyloidosisArrhythmiaCardiovascular therapyHeartHeart diseasesHeart failureIschemiaLongitudinal studiesMedical servicesPacemakers ePublished: 1 December 2008 Issue Published: 1 July 1966 PDF downloadLoading ...