A positive family history of NIDDM in healthy young adults is associated with significantly decreased aortic distensibility compared to those without such history (Cp 0.22 vs. 0.25, P=0.02).
Cross-Sectional (n=67)
Is a family history of NIDDM associated with decreased aortic distensibility in healthy young adults?
A positive family history of NIDDM is associated with decreased aortic distensibility (stiffer arteries) in healthy young adults, suggesting early vascular changes prior to the onset of clinical disease.
Absolute Event Rate: 0.22% vs 0.25%
p-value: p=0.02
OBJECTIVE: NIDDM is associated with stiffer arteries and an increased incidence of macrovascular disease. NIDDM has strong familial inheritance. We studied the associations of a family history of NIDDM with blood pressure-corrected aortic distensibility (Cp). RESEARCH DESIGN AND METHODS: Because age is a strong determinant of arterial distensibility, we studied an age-select cohort of 67 healthy normotensive normoglycemic young adults along with fasting measurements of glucose and insulin concentrations. Cp was calculated from noninvasive Doppler ultrasound measurements of pulse wave velocity along the descending thoracoabdominal aorta. RESULTS: The mean age of the subjects was 20.6 +/- 0.7 (mean +/- SD) years. A total of 22 subjects gave a positive family history of NIDDM in a parent or grandparent. Subjects with a positive family history of NIDDM had significantly less distensible (i.e., stiffer) aortas than their age- and sex-matched counterparts who gave no family history of NIDDM (Cp dimensionless: 0.22 +/- 0.04 vs. 0.25 +/- 0.04, P = 0.02). Subjects with a positive family history of NIDDM also had significantly higher fasting glucose (5.1 +/- 0.4 vs. 4.9 +/- 0.4 mmol/l, P = 0.009) and insulin (7.5 +/- 5.5 vs. 4.2 +/- 2.0 mU/l, P = 0.02) levels and BMIs (23.2 +/- 2.3 vs 21.1 +/- 2.5 kg/m2, P = 0.002). On multivariate regression analysis, family history of NIDDM (P = 0.03) was the only significant independent predictor of Cp. CONCLUSIONS: A positive family history of NIDDM is associated with decreased aortic distensibility in early adult life. The relevance of these observations to future cardiovascular events merits further investigation.
Hopkins et al. (Wed,) conducted a cross-sectional in Healthy normotensive normoglycemic young adults (n=67). Positive family history of NIDDM vs. No family history of NIDDM was evaluated on Blood pressure-corrected aortic distensibility (Cp) (p=0.02). A positive family history of NIDDM in healthy young adults is associated with significantly decreased aortic distensibility compared to those without such history (Cp 0.22 vs. 0.25, P=0.02).