Post-ablation atrial fibrillation occurred in 46% of patients with pre-ablation AF compared to 22.5% of those with isolated typical atrial flutter (P=0.001).
Cohort (n=192)
Does the presence of preablation atrial fibrillation affect the long-term occurrence of atrial fibrillation after typical atrial flutter ablation?
Catheter ablation for typical atrial flutter provides long-term freedom from atrial fibrillation in over 75% of patients without prior AF, and significantly reduces AF burden, hospitalizations, and symptoms in those with a history of AF.
Absolute Event Rate: 46% vs 22.5%
p-value: p=0.001
OBJECTIVE: Although catheter ablation is an effective treatment for typical atrial flutter (TFL), atrial fibrillation may occur during follow-up. The aim of this study was to assess the frequency of postablation atrial fibrillation in patients with or without atrial fibrillation before TFL ablation. METHODS: One hundred and ninety-two patients (135 men, age 68 ± 9 years) ablated for TFL were divided into two groups: group 1 (80 patients) with isolated TFL and group 2 (112 patients) with TFL and atrial fibrillation before ablation. The end-point of the study was the occurrence of documented atrial fibrillation after ablation. Several predetermined variables were tested with regard to atrial fibrillation occurrence. The patients' perception of the frequency and severity of arrhythmia-related symptoms was evaluated before and after ablation by means of the Symptom Checklist Frequency and Severity scale (SCFSS). RESULTS: At least one episode of atrial fibrillation was recorded in 18 (22.5%) group 1 and 52 (46%) group 2 patients (P = 0.001), during a follow-up of 1086 ± 825 and 1126 ± 962 days, respectively. On multivariate analysis, independent predictors of atrial fibrillation occurrence in group 1 were the number of preablation episodes of TFL and the younger age of the patients. The 37 group 2 patients who continued to have paroxysmal or persistent atrial fibrillation episodes after ablation showed a significant decrease in atrial fibrillation incidence and hospitalizations. SCFSS significantly improved in the 63 group 2 patients in whom it was evaluated. CONCLUSIONS: On long-term follow-up, after ablation of isolated TFL, more than three-quarters of patients remained free from atrial fibrillation. Conversely, in patients with preablation atrial fibrillation, TFL ablation reduced the number of atrial fibrillation episodes as well as the number of hospitalizations and arrhythmia-related symptoms.
Bandini et al. (Wed,) conducted a cohort in Typical atrial flutter (n=192). Catheter ablation vs. Isolated typical atrial flutter was evaluated on Occurrence of documented atrial fibrillation after ablation (p=0.001). Post-ablation atrial fibrillation occurred in 46% of patients with pre-ablation AF compared to 22.5% of those with isolated typical atrial flutter (P=0.001).