Antidepressant use or prescription among acute coronary syndrome patients increased from less than 5% prior to 1995 to 10-15% after 2000, with higher rates in North America compared to Europe.
Systematic Review
The prevalence of antidepressant use or prescription among ACS patients has increased considerably over time, reaching 10% to 15% by 2005, with higher rates observed in North America compared to Europe.
Effect estimate: 6.1% (95% CI 4.3-7.9)
BACKGROUND AND OBJECTIVES: Depression is common among acute coronary syndrome (ACS) patients and is associated with poor prognosis. Cardiac side effects of older antidepressants were well-known, but newer antidepressants are generally thought of as safe to use in patients with heart disease. The objective was to assess rates of antidepressant use or prescription to patients within a year of an ACS. METHODS: PubMed, PsycINFO, and CINAHL databases searched through May 29, 2009; manual searching of 33 journals from May 2009 to September 2010. Articles in any language were included if they reported point or period prevalence of antidepressant use or prescription in the 12 months prior or subsequent to an ACS for ≥100 patients. Two investigators independently selected studies for inclusion/exclusion and extracted methodological characteristics and outcomes from included studies (study setting, inclusion/exclusion criteria, sample size, prevalence of antidepressant prescription/use, method of assessing antidepressant prescription/use, time period of assessment). RESULTS: A total of 24 articles were included. The majority were from North America and Europe, and most utilized chart review or self-report to assess antidepressant use or prescription. Although there was substantial heterogeneity in results, overall, rates of antidepressant use or prescription increased from less than 5% prior to 1995 to 10-15% after 2000. In general, studies from North America reported substantially higher rates than studies from Europe, approximately 5% higher among studies that used chart or self-report data. CONCLUSIONS: Antidepressant use or prescription has increased considerably, and by 2005 approximately 10% to 15% of ACS patients were prescribed or using one of these drugs.
Czarny et al. (Tue,) conducted a systematic review in Acute Coronary Syndrome. Antidepressant prescription or use was evaluated on Pooled prevalence of antidepressant use (17 studies from 1997 onward) (6.1%, 95% CI 4.3-7.9). Antidepressant use or prescription among acute coronary syndrome patients increased from less than 5% prior to 1995 to 10-15% after 2000, with higher rates in North America compared to Europe.