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Taken together, we have identified a novel brain-enriched RING finger E3 ligase, which was up regulated in AD brains and neuronal cells exposed to injurious insults. It interacted with ATP6V0C protein suggesting that it may play a very specific role in controlling the turnover of an essential component of neurotransmitter release machinery.
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Qing Liu
Suihua University
Joy X Lei
National Research Council Canada
Marianna Sikorska
Medical Council of Canada
SHILAP Revista de lepidopterología
Molecular Neurodegeneration
University of Ottawa
University of North Dakota
Institute for Biological Sciences
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Liu et al. (Tue,) studied this question.
synapsesocial.com/papers/69deacf97702a00918b0c7d1 — DOI: https://doi.org/10.1186/1750-1326-3-4