Key points are not available for this paper at this time.
Since the isolation of a strain ofCephalosporium acremoniumby Brotzu in 1945,1the recovery of seven natural antibiotic substances from this fungus has been reported.2One of these antibiotic substances is cephalosporanic acid.3This nucleus is chemically closely related to the penicillin nucleus, 6-aminopenicillanic acid, differing by having a fused dihydrothiazine B lactam ring, rather than a fused thiazolidine B lactam ring.4Synthetic manipulation of the 7-aminocephalosporin nucleus by Chauvette et al5has resulted in the development of cephalothin (Keflin), now available commercially in the United States. A second important derivative, cephaloridine, chemically 7-α-(2-Thienyl) acetamido-3-(1-pyridylmethyl)-3-cephem-4-carboxylic acid betaine, has been produced in England and has been the subject of several favorable clinical reports from that country.6,7 Cephaloridine has essentially the same spectrum of antimicrobial activity as cephalothin, but is more potent against gram-positive organisms. Generally, the pharmacological properties of the two drugs are similar.
James B. Lucas (1966) studied this question.