Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts

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Abstract

The results of this study indicate that epigenetic mechanisms may mediate the fibrotic manifestations of SSc. The signal transduction leading to the SSc fibrotic phenotype appears to converge on DNA methylation and histone deacetylation at the FLI1 gene.

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Wang et al. (Tue,) studied this question.

synapsesocial.com/papers/69d93ad97fca1f84ab6846dd https://doi.org/https://doi.org/10.1002/art.21948

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