January 1, 1996
View Full PaperThe association between cardiorespiratory fitness and prostate cancer
Structured PICO
Do higher cardiorespiratory fitness and physical activity levels reduce the incidence of prostate cancer in adult men?
P
Population
12,975 men, aged 20-80 years, who received a preventive medical exam at the Cooper Clinic in Dallas, TX, during 1970-1989
I
Intervention
Higher cardiorespiratory fitness levels (assessed by maximal exercise treadmill test) and higher physical activity levels
C
Comparator
Lower cardiorespiratory fitness levels and lower physical activity levels (< 1000 kcal/week)
O
Outcome
Incident prostate cancerhard clinical
Higher cardiorespiratory fitness and physical activity levels are associated with a significantly reduced risk of incident prostate cancer, particularly in men under 60 years of age.
Abstract
We conducted a prospective study to assess the association between cardiorespiratory fitness and prostate cancer. The subjects were men, aged 20-80 yr, who received a preventive medical exam at the Cooper Clinic in Dallas, TX, during 1970-1989 and provided information on cardiorespiratory fitness and prostate cancer (N = 12,975). Cardiorespiratory fitness was assessed at a baseline examination between 1971 and 1989 using a maximal exercise treadmill test. Questionnaires were mailed to the men in 1982 and 1990 to ascertain incident cases of prostate cancer. Ninety-four cases of incident prostate cancer were identified. Higher cardiorespiratory fitness levels were inversely associated with the probability of development of incident prostate cancer after controlling for age, body mass index, and smoking habits; adjusted estimates of the incidence rate ratio declined from 1.1 (95% CI 0.63-1.77) to 0.73 (95% CI 0.41-1.29) to 0.26 (95% CI 0.10-0.63) across increasing quartiles of fitness (P for trend or = 3000 kcal.wk-1 had adjusted incidence rate ratios of 0.37 (95% CI 0.17-0.79), 0.62 (95% CI 0.27-1.41), and 0.37 (95% CI 0.14-0.98), respectively. The results suggest that cardiorespiratory fitness and physical activity levels may protect against the development of incident prostate cancer.