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SummaryRF mice exposed to 100-300 r of whole-body X-rays at various ages from before birth to 180 days after birth showed age-dependent variations in susceptibility to leukemia induction. Susceptibility to induction of granulocytic leukemia was minimal when irradiation was carried out during gestation or shortly after birth, rising later to a maximum at about 70 days of age. Susceptibility to induction of thymic lymphomas was, likewise, apparently minimal during gestation but maximal shortly after birth, declining later in life at the time of thymic involution. Susceptibility to induction of ovarian tumors was relatively low in mice irradiated in utero.We are grateful to F. F. Wolff, E. S. Ledford, and W. D. Gude for technical assistance and to Dr. A. W. Kimball for statistical analysis of data.
Upton et al. (Mon,) studied this question.