Intravenous enalaprilat reduced mean blood pressure from 226/141 mm Hg to 169/112 mm Hg in patients with severe or malignant hypertension, with no adverse side effects or symptomatic hypotension.
Does intravenous enalaprilat reduce blood pressure in patients with severe or malignant hypertension?
Intravenous enalaprilat effectively and safely reduces blood pressure in patients with severe or malignant hypertension.
The effect of enalaprilat (MK-422), a newly synthesized, intravenous, nonsulfhydryl, angiotensin-converting enzyme inhibitor, was studied in seven patients with either severe or malignant hypertension. All subjects initially received a 1 mg bolus injection of enalaprilat followed in 30 minutes by 10 mg. Five subjects received an additional 40 mg. Mean (+/- SE) pretreatment blood pressure for the group was 226 +/- 9/141 +/- 7 mm Hg. Five minutes after the 1 mg enalaprilat dose, blood pressure decreased to 211 +/- 10/131 +/- 9 mm Hg and further fell to 201 +/- 14/123 +/- 11 mm Hg at 30 minutes. The maximal reduction in blood pressure to 169 +/- 14/112 +/- 10 mm Hg occurred 30 minutes after the 10 mg dose. No further blood pressure reduction was observed in those subjects who received the additional 40 mg dose. Within the entire group, five subjects exhibited sustained blood pressure reduction. No adverse side effects or symptomatic hypotension occurred in any subject.
DiPette et al. (Thu,) conducted a other in Severe or malignant hypertension (n=7). Enalaprilat was evaluated on Blood pressure reduction. Intravenous enalaprilat reduced mean blood pressure from 226/141 mm Hg to 169/112 mm Hg in patients with severe or malignant hypertension, with no adverse side effects or symptomatic hypotension.