Insulin-mediated glucose uptake was positively associated with carotid artery compliance (standardized beta 0.21, P=0.05), and alcohol use was negatively associated with femoral artery compliance.
Cross-Sectional (n=81)
Are metabolic variables such as insulin resistance and postprandial triglyceridaemia associated with increased arterial stiffness in patients with type 2 diabetes mellitus?
In patients with type 2 diabetes, insulin resistance and alcohol use are associated with increased arterial stiffness, whereas fasting or postprandial triglyceridaemia are not.
Effect estimate: Standardized beta 0.21
p-value: p=0.05
BACKGROUND: Type 2 diabetes mellitus is associated with an increased risk of atherothrombotic disease, which may in part be mediated through increased arterial stiffness. We investigated to what extent increased arterial stiffness is associated with cardiovascular risk factors that commonly cluster in type 2 diabetes. DESIGN: In this cross-sectional, observational study we assessed, in 81 subjects with type 2 diabetes, local distensibility and compliance of the common carotid and femoral arteries, and carotido-femoral transit time. We subsequently investigated whether these measures of arterial stiffness were determined by diabetes duration, blood pressure, lipid levels (including fasting and postprandial triglyceridaemia), hyperglycaemia, BMI, waist-to-hip ratio, insulin resistance (as measured by a euglycaemic, hyperinsulinaemic clamp), hyperinsulinaemia, cigarette smoking, or the use of alcohol. RESULTS: In multivariate analysis, insulin-mediated glucose uptake was positively standardized beta, 0.21 (P = 0.05) associated with the carotid artery compliance coefficient, and the use of alcohol was negatively associated with the femoral artery compliance coefficient standardized beta, -0.25 (P = 0.03). Except for mean arterial pressure, which was negatively associated with all outcome variables, the other cardiovascular risk factors that we investigated were not significantly associated with the distensibility coefficients of both the carotid and femoral artery, or with the carotido-femoral transit time. CONCLUSIONS: In subjects with type 2 diabetes mellitus, insulin resistance and the use of alcohol were associated with increased arterial stiffness, which supports the hypothesis that increased arterial stiffness can act as a mediating factor in the association between type 2 diabetes mellitus and increased risk of atherothrombotic disease. We found no evidence for an association between fasting or postprandial triglyceridaemia and arterial stiffness.
Dijk et al. (Fri,) conducted a cross-sectional in Type 2 diabetes mellitus (n=81). Metabolic variables and cardiovascular risk factors was evaluated on Arterial stiffness (carotid and femoral artery compliance and distensibility, carotido-femoral transit time) (Standardized beta 0.21, p=0.05). Insulin-mediated glucose uptake was positively associated with carotid artery compliance (standardized beta 0.21, P=0.05), and alcohol use was negatively associated with femoral artery compliance.
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