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Progress on the Human Genome Project has led to an explosion of genetic information (1). Of the estimated 100,000 human genes, more than 9,000 have been discovered, and more than 5,000 have been mapped to specific chromosomes (2). There are approximately 500 genes for which there are genetic tests used in medical practice (3). Almost daily, discoveries are announced for gene variants that affect the risks of diseases of major public health importance, from adult chronic diseases such as cancer and diabetes mellitus to infectious and immunologic disorders, as well as diseases affecting the health of infants and children. Most discoveries of gene variants are based on studies of high-risk families or selected groups. In order to translate the results of this genetic research into opportunities for treating and preventing disease and promoting health, population-based epide-
Khoury et al. (Wed,) studied this question.
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