Aging had a stronger correlation with central aortic pulse wave velocity (r=0.474, P<0.001) than with peripheral radial pulse wave velocity (r=0.224, P=0.003).
Observational (n=175)
Does aging have differing effects on central versus peripheral blood pressures and pulse wave velocity?
Aging has a greater effect on central rather than peripheral arterial hemodynamics, predominantly affecting central pulse pressure due to central arterial stiffness.
Effect estimate: r = 0.474
p-value: p=<0.001
OBJECTIVES: There have been a few noninvasive studies showing the effect of aging on blood pressure (BP) and pulse wave velocity (PWV) in different arterial segments. The aim of this study was to evaluate the effect of aging on arterial hemodynamics in central and peripheral arteries using an invasive method. METHODS: We observed 175 individuals undergoing coronary angiography. SBP and DBP were measured by pressure wave at the radial artery, abdominal aorta, and aortic arch. Aortic arch-abdominal aorta PWV (aoPWV) and aortic arch-radial artery PWV (arPWV) were also assessed by the foot-to-foot velocity method using a fluid-filled system. RESULTS: SBP and pulse pressure were significantly positively correlated and DBP was significantly negatively correlated with age through the arterial tree in a multivariate analysis after adjusting for sex, coronary artery disease, diabetes, dyslipidemia, smoking status, and the use of antihypertensive agents. Pulse pressure, SBP, and DBP were significantly associated with age (ranked in order of association strength) at all studied arterial segments. Each central BP showed a consistently higher correlation with age than radial BP. aoPWV and arPWV were also significantly correlated with age, and this relationship was much stronger for aoPWV (r = 0.474, P < 0.001) than for arPWV (r = 0.224, P = 0.003). CONCLUSION: The present invasive study suggests that aging has a greater effect on central rather than peripheral arterial hemodynamics. The central pulse pressure was the predominant BP affected by aging, which could be caused by the stronger relationship of aging with central arterial stiffness.
Choi et al. (Fri,) conducted a observational in Undergoing coronary angiography (n=175). Aging was evaluated on Correlation of age with aortic arch-abdominal aorta pulse wave velocity (aoPWV) (r = 0.474, p=<0.001). Aging had a stronger correlation with central aortic pulse wave velocity (r=0.474, P<0.001) than with peripheral radial pulse wave velocity (r=0.224, P=0.003).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: