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The susceptibility of LDL to in vitro oxidation shows marked differences between individuals. These differences may be due to the manifestation of characteristic properties of LDL, determined at least in part by genetic factors. Dense LDL, predominant in phenotype B, is more susceptible to oxidation than the less dense LDL, predominant in phenotype A. Studies on the basis of such differences, population studies and case-control studies would benefit from a better knowledge of the mechanism of LDL oxidation, a clear definition of the term 'susceptibility to oxidation' and a consensus on fully standardized assays. On the basis of a theoretical concept, we discuss mechanistic aspects of 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH)- and Cu2 +-mediated LDL oxidation and some factors controlling the rate of LDL oxidation.
Esterbauer et al. (Thu,) studied this question.