Increasing left ventricular volume significantly increased the slope of the right ventricular end-systolic pressure-volume relation (from 2.63 to 2.89 mm Hg/ml; p<0.01).
Does left ventricular volume affect right ventricular end-systolic pressure-volume relation in a canine model?
In a canine model, increasing left ventricular volume significantly increases the slope of the right ventricular end-systolic pressure-volume relation and decreases its volume intercept, demonstrating ventricular interdependence.
p-value: p=<0.01
Effect of left ventricular (LV) volume on right ventricular (RV) end-systolic pressure-volume relation (ESPVR) was investigated, and the mechanism was examined from a standpoint of the alteration of RV free wall mean fiber length. Twelve cross-circulated isovolumically contracting canine hearts in which both ventricular volumes were controlled independently were used, and RV-ESPVR was determined at three different LV volume levels. At small (10.2 +/- 0.6 ml), middle (15.3 +/- 1.0 ml), and large (20.5 +/- 1.4 ml) LV volume, the slope of the RV-ESPVR was 2.63 +/- 0.13, 2.74 +/- 0.13, and 2.89 +/- 0.12 mm Hg/ml, respectively, and each value was significantly different from the others (p less than 0.01). The volume intercept (V0) of the relation (RV-V0) was significantly decreased with the increment of LV volume (RV-V0 in small, middle, and large LV volume; 3.92 +/- 0.68, 3.39 +/- 0.67, and 2.87 +/- 0.71 ml, respectively; p less than 0.01). In nine hearts, RV free wall lengths in latitudinal and meridional direction were measured at three LV volume levels when RV volume was held constant (16.1 +/- 1.1 ml). RV latitudinal end-diastolic length was significantly augmented with increasing LV volume (latitudinal length in small, middle, and large LV volume; 9.68 +/- 0.55, 9.81 +/- 0.56, and 9.92 +/- 0.55 mm, respectively). RV meridional end-diastolic length also increased significantly with increasing LV volume.(ABSTRACT TRUNCATED AT 250 WORDS)
Yamaguchi et al. (Fri,) reported a other. Left ventricular volume alteration vs. Different volume levels was evaluated on Right ventricular end-systolic pressure-volume relation (ESPVR) slope and volume intercept (V0) (p=<0.01). Increasing left ventricular volume significantly increased the slope of the right ventricular end-systolic pressure-volume relation (from 2.63 to 2.89 mm Hg/ml; p<0.01).