Hypertension and higher body mass index jointly increased the 5-year risk of coronary heart disease, with hypertensive men in the highest BMI tertile having an RR of 1.61 (95% CI 1.04-2.50).
Cohort (n=9,758)
Yes
Do body mass index and hypertension jointly increase the risk of incident coronary heart disease in middle-aged men?
Hypertension and overweight jointly increase the risk of incident coronary heart disease in middle-aged men, with hypertension modifying the CHD risk attributable to BMI.
Effect estimate: RR 1.61 (95% CI 1.04-2.50)
p-value: p=<0.05
OBJECTIVE: The aim of the present study was to assess the joint contribution of hypertension and body mass index to coronary heart disease risk. DESIGN Prospective study on men aged 50-59 years free of coronary heart disease at entry recruited in three regions of France (n = 7359) and in Northern Ireland (n = 2399). PARTICIPANTS: The recruitment frame was based on industry and various employment groups, on health screening centers and general practice. MAIN OUTCOME: Incident cases of effort angina, unstable angina, myocardial infarction and coronary death were recorded over a 5-year follow-up. RESULTS: Compared with the reference group body mass index (BMI) 25 kg/m2, the relative risk of coronary event was higher in the second (25 < or =BMI 27.6) and third BMI tertiles: 1.27 (95% confidence interval 0.94-1.70) and 1.14 (0.84-1.56) after adjustment for confounders and covariates, including diabetes, hypertension and lipoprotein levels. Further analyses revealed a significant interaction between hypertension and BMI on coronary disease risk (P <0.05), suggesting that hypertension modifies coronary heart disease (CHD) risk attributable to BMI. Among hypertensive men, the relative risk of coronary heart disease was 1.34 (0.85-2.11) and 1.61 (1.04-2.50) in the second and third BMI tertiles, respectively. In normotensive men, BMI was not associated with CHD risk; relative risk 1.25 (0.85-1.85) and 0.66 (0.40-1.09) in the second and third BMI, respectively. CONCLUSION: These results indicate that hypertension and overweight jointly increase coronary heart disease risk.
Mahamat et al. (Sat,) conducted a cohort in Coronary heart disease (n=9,758). Higher body mass index and hypertension vs. BMI < 25 kg/m2 and normotension was evaluated on Incident cases of effort angina, unstable angina, myocardial infarction and coronary death (RR 1.61, 95% CI 1.04-2.50, p=<0.05). Hypertension and higher body mass index jointly increased the 5-year risk of coronary heart disease, with hypertensive men in the highest BMI tertile having an RR of 1.61 (95% CI 1.04-2.50).