Key points are not available for this paper at this time.
Editorials1 October 1984Acute Lymphoblastic Leukemia in AdultsROBERT J. MAYER, M.D.ROBERT J. MAYER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-4-552 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptConsiderable progress has been made during the last 20 years in the treatment of children with acute lymphoblastic leukemia. More than 90% of such patients have complete remission, and 55% to 60% of the complete responders appear to be cured after central nervous system prophylaxis and chemotherapy for 24 to 30 months after remission (1). Various clinical and laboratory features seen at the time of diagnosis have permitted the classification of children with this disease into subsets with a "standard" or "high" risk for relapse (2). Adverse features include a high leukocyte count ( > 20 000/µL), age less than...References1. SALLANCAMITTACASSADYNATHANFREI SBJDE. Intermittent combination chemotherapy with adriamycin for childhood acute lymphoblastic leukemia: clinical results. Blood. 1978;51:425-33. MedlineGoogle Scholar2. MAUER A. Therapy of acute lymphoblastic leukemia in childhood. Blood. 1980;56:1-10. CrossrefMedlineGoogle Scholar3. GEEHAGHBINDOWLINGCUNNINGHAMMIDDLEMANCLARKSON TMMIMB. Acute lymphoblastic leukemia in adults and children: differences in response with similar therapeutic regimens. Cancer. 1976;37:1256-64. CrossrefMedlineGoogle Scholar4. BENNETTCATOVSKYDANIEL JDM. Proposals for the classification of the acute leukaemias: French-American-British (FAB) co-operative group. Br J Haematol. 1976;33:451-8. CrossrefMedlineGoogle Scholar5. BENNETTCATOVSKYDANIEL JDM. The morphological classification of acute lymphoblastic leukaemia: concordance among observers and clinical correlations. Br J Haematol. 1981;47:553-61. CrossrefMedlineGoogle Scholar6. LEIMERTBURNSWILTSEARMITAGECLARKE JCCJW. Prognostic influence of pretreatment characteristics in adult acute lymphoblastic leukemia. Blood. 1980;56:510-5. CrossrefMedlineGoogle Scholar7. BACCARANICORBELLIAMADORI MGS. Adolescent and adult acute lymphoblastic leukemia: prognostic features and outcome of therapy: a study of 293 patients. Blood. 1982;60:677-84. CrossrefMedlineGoogle Scholar8. BURNSGINGRISHARMITAGE CRJ. Adverse effect of T-cell markers in adult acute lymphoblastic leukemia Abstract. Proc Am Soc Clin Oncol. 1984;3:209. Google Scholar9. SALLANRITZPESANDO SJJ. Cell-surface antigens: prognostic implications in childhood acute lymphoblastic leukemia. Blood. 1980;55:395-402. CrossrefMedlineGoogle Scholar10. GREAVESLISTER MT. Prognostic importance of immunologic markers in adult acute lymphoblastic leukemia Letter. N Engl J Med. 1981;304:119-20. CrossrefMedlineGoogle Scholar11. GREAVESBROWNRAPSONLISTER MGNT. Antisera to acute lymphoblastic leukemia cells. Clin Immunol Immunopathol. 1975;4:67-84. CrossrefMedlineGoogle Scholar12. KERSEYGOLDMANABRAMSON JAC. Clinical usefulness of monoclonal-antibody phenotyping in childhood acute lymphoblastic leukaemia. Lancet. 1982;2:1419-23. CrossrefMedlineGoogle Scholar13. NADLERRITZBATES LJM. Induction of human B cell antigens in non-T cell acute lymphoblastic leukemia. J Clin Invest. 1982;70:433-42. CrossrefMedlineGoogle Scholar14. KORSMEYERARNOLDBAKHSHI SAA. Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins. J Clin Invest. 1983;71:301-13. CrossrefMedlineGoogle Scholar15. BLOOMFIELDROWLEYGOLDMANLAWLERSECKER WALKERMITELMAN CJASLF. Chromosomal abnormalities and their clinical significance in acute lymphoblastic leukemia. Cancer Res. 1983;43:868-73. MedlineGoogle Scholar16. TAUBKIRSCHMORTON RIC. Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc Natl Acad Sci USA. 1982;79:7837-41. CrossrefMedlineGoogle Scholar17. WILLEMZEHILLENHARTGRINK-GROENEVELDHAANEN RHCC. Treatment of acute lymphoblastic leukemia in adolescents and adults: a retrospective study of 41 patients (1970-1973). Blood. 1975;46:823-34. CrossrefMedlineGoogle Scholar18. HOELZERTHIELLÖFFLER DEH. Intensified therapy in acute lymphoblastic and acute undifferentiated leukemia in adults. Blood. 1984;64:38-46. CrossrefMedlineGoogle Scholar19. LISTERWHITEHOUSEBEARD TJM. Combination chemotherapy for acute lymphoblastic leukaemia in adults. Br Med J. 1978;1:199-203. CrossrefMedlineGoogle Scholar20. MAYERCORALROSENTHALSALLANFREI RFDSE. Treatment of non-T, non-B cell acute lymphocytic leukemia (ALL) in adults Abstract. Proc Am Soc Clin Oncol. 1982;1:126. Google Scholar21. SCHAUERARLINMERTELSMANN PZR. Treatment of acute lymphoblastic leukemia in adults: results of the L-10 and L-10M protocols. J Clin Oncol. 1983;1:462-70. CrossrefMedlineGoogle Scholar22. RITZSALLANBAST JSR. Autologous bone-marrow transplantation in CALLA-positive acute lymphoblastic leukaemia after in-vitro treatment with J5 monoclonal antibody and complement. Lancet. 1982;2:60-3. CrossrefMedlineGoogle Scholar23. THOMASSANDERSFLOURNOY EJN. Marrow transplantation for patients with acute lymphoblastic leukemia: a long-term follow-up. Blood. 1983;62:1139-41. CrossrefMedlineGoogle Scholar24. RIEHMGADNERHENZELANGERMANNODENWALD HHGHE. The Berlin childhood acute lymphoblastic leukemia therapy study, 1970-1976. Am J Pediatr Hematol Oncol. 1980;2:299-306. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Dana-Farber Cancer Institute Harvard Medical School Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByBone Marrow Transplantation for Philadelphia Chromosome Positive Acute Lymphoblastic LeukemiaAdult Acute Lymphoblastic Leukemia: Results of an Aggressive Regimen in IndiaSerum pseudouridine in the diagnosis of acute leukaemias and as a novel prognostic indicator in acute lymphoblastic leukaemiaHyperexpression of interleukin-7 is not necessary or sufficient for transformation of a pre-B lymphoid cell lineDiagnosis and treatment of adult acute leukemiaOncologic Problems in the ElderlyUrinary Nucleosides in Leukemia: Laboratory and Clinical Applications 1 October 1984Volume 101, Issue 4Page: 552-554KeywordsCentral nervous systemChemotherapyChildrenClinical laboratoriesPrecursor cellsProphylaxisResearch laboratories Issue Published: 1 October 1984 PDF DownloadLoading ...
Robert J. Mayer (Mon,) studied this question.