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Abstract— Primary cultures of rat brain astrocytes were used to examine the uptake of the glucose analogue, 2‐deoxy‐ d ‐glucose (2‐DOG). 2‐DOG competes with glucose for uptake, indicating that both are transported by the same carrier system. Extracellular K + at 11.9 mM increased the uptake of 2‐DOG at 2‐DOG concentrations greater than 100 μM. Uptake. appears Na + ‐dependent only at high concentrations of 2‐DOG. This suggests that the extracellular concentrations of Na + and K + may regulate the astrocytic uptake of 2‐DOG.
Cummins et al. (Sat,) studied this question.