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Neuroendocrine mechanisms involved in the reduction of testosterone (T) levels induced by the chronic surgical stress of s.c. gauze implantation were investigated in male rats. The reduction resulted from a decline in T secretion and not an increase in clearance of the hormone from the circulation. In most cases, the decrement was accompanied by a reduction in LH levels, indicating that decreased LH stimulation is the primary factor mediating the drop in T levels. The suppressive effect of surgical stress on LH and T levels was apparently not mediated by the pituitary-adrenal system.
Gray et al. (Tue,) studied this question.