Vzasodilator Therapy for Heart Failure

Editorials1 September 1975Vzasodilator Therapy for Heart FailureKANU CHATTERJEE, M.B., M.R.C.P., F.A.C.P.KANU CHATTERJEE, M.B., M.R.C.P., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-3-421 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPathophysiologic consequences and clinical manifestations of "cardiac pump failure" can be related to reduced cardiac output and elevated pulmonary and systemic venous pressures. The major objectives of therapy for pump failure, therefore, are to improve cardiac output and decrease venous pressures. Improvement in cardiac output can be achieved in appropriate circumstances by increasing heart rate, ventricular diastolic volume (Frank-Starling mechanism), and contractile state. In addition, cardiac output can be improved by decreasing the external factors that oppose shortening of the myocardial fibers and ventricular ejection (afterload).Systemic vascular resistance is one of these major external factors that play an important...References1. FRANCIOSA J, GUIHA N, and LIMAS C: Improved left ventricular function during nitroprusside infusion in acute myocardial infarction. Lancet 1:650-654, 1972 CrossrefMedlineGoogle Scholar2. CHATTERJEE K, PARMLEY W, and GANZ W: Hemodynamic and metabolic responses to vasodilator therapy in acute myocardial infarction. Circulation 48:1183-1193, 1973 CrossrefMedlineGoogle Scholar3. FLAHERTY J, REID P, and KELLY D: Intravenous nitroglycerin in acute myocardial infarction. Circulation 51:132-139, 1975 CrossrefMedlineGoogle Scholar4. CHATTERJEE K and SWAN H: Vasodilator therapy in acute myocardial infarction. Mod Concepts Cardiovasc Dis 43:119-124, 1974 MedlineGoogle Scholar5. 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Ann Intern Med 81:777-780, 19 4 LinkGoogle Scholar11. GRAY R, CHATTERJEE K, and VYDEN J: Hemodynamic and metabolic effects of isosorbide dinitrate in chronic congestive heart failure. Am Heart J, in press Google Scholar12. FRANCIOSA J, MIKULIC E, and COHN J: Hemodynamic effects of orally administered isosorbide dinitrate in patients with congestive heart failure. Circulation 50:1020-1024, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: KANU CHATTERJEE, M.B., M.R.C.P., F.A.C.P.Affiliations: Division of Cardiology University of California San Francisco, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFelodipine in patients with chronic heart failure: discrepant haemodynamic and clinical effects.Pharmacologic Support of the Myocardium Following Aortocoronary Bypass Surgery: A Comparative StudyThe search for an ideal oral positive inotropic agentCardiogenic shockCAPTOPRIL—A NEW TREATMENT FOR SEVERE CONGESTIVE HEART FAILUREComparative hemodynamic effects of digoxin vs nitroprusside in conscious dogs with aortocaval fistula-induced chronic left ventricular volume overload and normal systolic performanceHemodynamic assessment of prenalterol: A cardioselective beta agonist in patients with impaired left ventricular functionEffects of sodium nitroprusside upon cardiac work, efficiency, and substrate extraction in severe left ventricular failure.Combined vasodilator and inotropic therapy of heart failure: Experimental and clinical conceptsClinical Experience of a New Inotropic Agent-Prenalterol-in-Hypotension and Heart FailureUse of oral prazosin hydrochloride in congestive failure following acute myocardial infarctionKombinierte Infusion von Nitroprussid-Natrium und Dobutamin zur Behandlung der hochgradigen Linksherzinsuffizienz bei koronarer HerzkrankheitSpecific afterload reduction with parenteral hydralazine following cardiac surgeryCombined nitroprusside-dopamine therapy in severe chronic congestive heart failureLong-term outpatient vasodilator therapy of congestive heart failureNitrate therapy of heart failure in valvular heart diseaseOutflow Resistance as a Regulator of Left Ventricular PerformanceUsefulness of long-acting nitrates in cardiovascular diseaseTreatment of chronic heart failure with slow release phentolamineComparative responses to dobutamine and nitroprusside in patients with chronic low output cardiac failure.Comparison of the cardiovascular effects of phentolamine, sodium nitroprusside and nitroglycerin in anaesthetized cats (Comparison of vasodilators)Vasodilator treatment for acute and chronic heart failure.The role of vasodilator therapy in heart failureOral hydralazine therapy for chronic refractory heart failure.Combination Vasodilator Therapy for Severe Chronic Congestive Heart FailureKANU CHATTERJEE, M.B., M.R.C.P., DENIS DREW, M.D., WILLIAM W. PARMLEY, M.D., STEVEN C. KLAUSNER, M.D., JON POLANSKY, M.D., BARRY ZACHERLE, M.D. 1 September 1975Volume 83, Issue 3 Page: 421-423 Keywords Cardiac output Heart failure Heart rate Systemic vascular resistance ePublished: 1 December 2008 Issue Published: 1 September 1975 PDF downloadLoading ...