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The phenomenon of single filing in carcinoma of the breast was demonstrated in 140 (3.2%) of 4320 patients seen at the Mayo Clinic between 1943 and 1957. The age distribution, symptoms and signs, gross pathologic findings and size of the tumors did not show different features from mammary carcinoma in general. Bilaterality was present in 15 patients (11%), which is a higher rate than in mammary carcinoma in general. Regional lymph nodes were metastatically involved in 51% of the group. Single filing is formed by desmoplastic strands of mostly medium-sized cells followed in frequency by small and large cells. Mitotic figures are rare. Single filing was found in connection with infiltrating or noninfiltrating lobular carcinomas in 21.2% and with areas of intraductal carcinomas in 36%. The prognostic outlook for patients without lymph node involvement is somewhat similar to that of patients having carcinoma of the breast in general; that for patients with positive lymph nodes is poor, with a 9% chance of 10-year survival.
Richter et al. (1967) studied this question.