Hypertension was the strongest metabolic syndrome component associated with ischemic heart disease in type 2 diabetic patients (age-adjusted OR 7.10; 95% CI 5.38-9.38; p<0.01).
Cross-Sectional (n=1,296)
Does metabolic syndrome and its individual components increase the risk of ischemic heart disease in Taiwanese patients with type 2 diabetes mellitus?
In Taiwanese patients with type 2 diabetes, metabolic syndrome is highly prevalent and strongly associated with ischemic heart disease, with hypertension being the most significant individual risk factor.
Effect estimate: OR 7.10 (95% CI 5.38-9.38)
p-value: p=<0.01
BACKGROUND: To evaluate the association between components of metabolic syndrome (MS) and ischemic heart disease (IHD) in Taiwanese patients with type 2 diabetes mellitus (T2DM). METHODS AND RESULTS: A total of 1,296 (604 men and 692 women) subjects with T2DM aged 62.5+/-11.7 (14-87) years were studied. MS was defined using the World Health Organization modified criteria and included more than 2 of hypertension, obesity, dyslipidemia and microalbuminuria. IHD was diagnosed through history or ischemic electrocardiogram according to the Minnesota codes. Results showed that MS was present in 76.2% and IHD in 36.3% of the patients, respectively. MS increased with age for both sexes, but there was no difference between men and women in the age groups of or=65 years. IHD prevalence was significantly higher in patients with MS, hypertension, dyslipidemia and obesity (p<0.01), and was higher with borderline significance for microalbuminuria (0.05<p<0.1). The respective age-adjusted odds ratios were 3.61 (2.57-5.08), 7.10 (5.38-9.38), 1.70 (1.32-2.18), 1.75 (1.33-2.28), and 1.11 (0.88-1.41). CONCLUSIONS: The prevalence of MS in subjects with T2DM is high and increases with age. The impact of different risk factors on IHD is diverse, with hypertension being the most important.
Tseng et al. (Tue,) conducted a cross-sectional in Type 2 diabetes mellitus (n=1,296). Metabolic syndrome components (specifically hypertension) vs. Absence of metabolic syndrome components was evaluated on Ischemic heart disease (IHD) (OR 7.10, 95% CI 5.38-9.38, p=<0.01). Hypertension was the strongest metabolic syndrome component associated with ischemic heart disease in type 2 diabetic patients (age-adjusted OR 7.10; 95% CI 5.38-9.38; p<0.01).
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