Longstanding pulmonary hypertension causes significant right atrial electrical and structural remodeling, providing mechanistic insights into its association with atrial fibrillation.
Idiopathic PH is associated with RA remodeling characterized by: generalized conduction slowing with marked regional abnormalities; reduced tissue voltage; and regions of electrical silence. These changes provide important insights into the isolated effects of PH fundamental to a range of clinical conditions associated with AF.
Medi et al. (Mon,) studied this question.