Intraocular Pressure and Its Relation to Retinal Extravasation

HIGH AND LOW INTRAOCULAR PRESSURE IN RELATION TO RETINOPATHY During my studies on anatomic changes of the optic nerve associated with general hypertension, I examined the eyes of a patient aged 42 who was admitted to a well known hospital four times in one and one-half years because of chronic glomerulonephritis with increased blood pressure and uremic attacks. On each new admission the nonprotein nitrogen of the blood was at a higher level, the last time being as high as 507 mg. of urea and 9.1 mg. of uric acid per hundred cubic centimeters. In spite of this enormous elevation of nonprotein nitrogen and the high blood pressure, ophthalmoscopic examination revealed no spots or hemorrhages in the retina ; even later, examination of many anatomic slides showed only one tiny group of "ganglioform nerve fibers." On the other hand, one could follow the development of a glaucomatous (from a physiologic) cupping