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Anacardic acids, 2-methylcardols, and cardols isolated from various parts of the cashew Anacardium occidentale (Anacardiaceae) fruit have been found to exhibit tyrosinase inhibitory activity. Kinetic studies with the two principal active compounds, 6-8(Z),11(Z),14-pentadecatrienylsalicylic acid and 5-8(Z),11(Z),14-pentadecatrienylresorcinol, have indicated that both of these phenolic compounds exhibit characteristic competitive inhibition of the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) by mushroom tyrosinase.
Kubo et al. (Fri,) studied this question.