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A fraction of the covalently closed mitochondrial DNA in mouse L cells contains a replicated heavy-strand segment that is hydrogen bonded to the circular light strand. The inserted single strand is dissociable from the circular duplex at an elevated temperature.
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Harumi Kasamatsu
University of California, Los Angeles
Donald L. Robberson
The University of Texas MD Anderson Cancer Center
Jerome Vinograd
The Wistar Institute
Proceedings of the National Academy of Sciences
California Institute of Technology
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Kasamatsu et al. (Wed,) studied this question.
synapsesocial.com/papers/6a19410cfa25ab5db6d94b50 — DOI: https://doi.org/10.1073/pnas.68.9.2252