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S Vaishnava, M Yamamoto, KM Severson. Science. 2011;334(6053):255–258 The mammalian intestine is home to ∼100 trillion bacteria that perform important metabolic functions for their hosts. The proximity of vast numbers of bacteria to host intestinal tissues raises the question of how symbiotic host-bacterial relationships are maintained without eliciting potentially harmful immune responses. The authors developed a strain of mice that did not express the RegIIIγ protein (“RegIIIγ(−/−)” mice). The authors then tested the effects of the gene deletion on …
James E. Gern (Mon,) studied this question.