Aging of human atrial myocardium is accompanied by a linear regression of nerve plexuses and a lifelong increase in collagen content and fibrosis.
Cross-Sectional (n=17)
Aging of the human atrial myocardium is accompanied by a decrease in nerve plexuses and an increase in fibrosis, even in the absence of clinical cardiac disease.
OBJECTIVE: The objective of this study was to analyse age-related changes in human myocardial nerve plexuses and collagen networks of the auricle of the right atrium in subjects in whom no cardiac diseases or pathology had been diagnosed. METHODS AND RESULTS: Morphometric analysis of acetylcholinesterase (AChE)-stained nerve plexuses and picrosirius-stained cardiac collagen networks from 17 persons of both genders aged 20-94 years was performed using video microscopy and a digital video camera. It was found that with age linear regression of nerve plexuses occurred.Atrial collagen content increases lifelong. CONCLUSION: Aging of human atrial myocardium is accompanied by a decrease of nerve plexuses and an increase in fibrosis.
BURKAUSKICNÉ et al. (Sun,) conducted a cross-sectional in No cardiac diseases or pathology (n=17). Aging was evaluated on Age-related changes in human myocardial nerve plexuses and collagen networks. Aging of human atrial myocardium is accompanied by a linear regression of nerve plexuses and a lifelong increase in collagen content and fibrosis.
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