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This paper reports the time course of development of the intramitochondrial cholesterol side‐chain‐cleavage activity, cytoplasmic NADP + ‐dependent isocitric dehydrogenase, malic enzyme and glucose‐6‐phosphate dehydrogenase during ovarian maturation, using as a model the immature rat ovary stimulated to develop with pharmacological doses of gonadotrophin. These enzymic activities were correlated with increases in ovarian content of DNA, cellular content of adenosine 3′:5′‐monophosphate, and the levels of plasma progesterone. The plasma progesterone concentrations followed closely the development of the 4‐ 14 Ccholesterol side‐chain‐cleavage which was mimicked by the cytoplasmic isocitric dehydrogenase; both enzymes increased in activity 28 times during the 6 days of this study. There was no correlation between adenosine 3′:5′‐monophosphate levels and cholesterol side‐chain cleavage or progesterone plasma concentrations.
Klinken et al. (Thu,) studied this question.