Synthesis and Structural Analysis of a New Class of Azaspiro3.3heptanes as Building Blocks for Medicinal Chemistry

Straightforward access toward previously unreported substituted, heterocyclic spiro3.3heptanes is disclosed. These spirocyclic systems may be considered as alternatives to 1,3-heteroatom-substituted cyclohexanes, which are otherwise insufficiently stable to allow their use in drug discovery. Conformational details are discussed on the basis of X-ray crystallographic structures.