Excess calorie intake and psychological stress in rats increased blood pressure, heart rate, and catecholamine levels (p < 0.05), supporting the concept of an excess catecholamine syndrome.
p-value: p=<0.05
In addition to genetic factors, lifestyle has a predominant influence on primary hypertension and noninsulin-dependent diabetic mellitus (NIDDM). We initiated studies using radiotelemetry for characterizing molecular events linked with excess calorie intake and psychologic stress. An increased calorie intake was associated with raised (p < 0.05) systolic and diastolic blood pressure as well as heart rate independent of day-night cycle. Sympathetic activity was in excess when related to the unchanged motility. The hyperkinetic hypertension is expected to result in adverse remodeling of resistance vessels and to aggravate insulin resistance. To examine adverse effects of psychological stress, rats were subjected to intermittent food pellet feeding. Urinary catecholamines and cardiac norepinephrine stores were increased (p < 0.05). The depressed (p < 0.05) rate of Ca2+ uptake of sarcoplasmic reticulum is expected to contribute to cellular Ca2+ overload. These lifestyle influences strengthen the notion of an excess catecholamine syndrome which requires selective reduction of sympathetic outflow of the brain by I1-receptor agonists.
Heinz Rupp (Tue,) conducted a other in Primary hypertension and noninsulin-dependent diabetic mellitus (NIDDM). Excess calorie intake and psychologic stress was evaluated on Blood pressure, heart rate, and catecholamine levels (p=<0.05). Excess calorie intake and psychological stress in rats increased blood pressure, heart rate, and catecholamine levels (p < 0.05), supporting the concept of an excess catecholamine syndrome.
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