The Multiple Risk Factor Intervention Trial (MRFIT) was designed to test whether a multifactor intervention prevents fatal coronary heart disease events in high-risk, asymptomatic middle-aged men.
RCT (n=12,866)
randomized
Does multifactor intervention prevent fatal coronary heart disease (CHD) events in high-risk, asymptomatic middle-aged men compared with usual care?
This paper reviews the historical context and design of the landmark MRFIT trial, which evaluated multifactor risk intervention for primary prevention of fatal CHD.
In 1982 the results of the landmark Multiple Risk Factor Intervention Trial (MRFIT) were published inJAMA.1MRFIT was a randomized primary prevention trial funded by the National Heart and Lung Institute (now the National Heart, Lung, and Blood Institute) to test whether multifactor intervention in 12 866 high-risk, asymptomatic middle-aged men would prevent fatal coronary heart disease (CHD) events compared with usual care. Minimum follow-up was 6 years. MRFIT grew from the Task Force on Arteriosclerosis convened in 1970 by the National Heart and Lung Institute to devise a long-range strategy for preventing, treating, and controlling arteriosclerosis and its complications.2The task force thoroughly reviewed data that had come from epidemiologic observations in the United States and abroad—including the findings of the Framingham Heart Study, the Seven Countries Study, and the Chicago Workers Study—and from clinical observations and smaller clinical trials linking risk factor modification
Antonio M. Gotto (Wed,) conducted a rct in High-risk, asymptomatic for coronary heart disease (n=12,866). Multifactor intervention vs. Usual care was evaluated on Fatal coronary heart disease (CHD) events. The Multiple Risk Factor Intervention Trial (MRFIT) was designed to test whether a multifactor intervention prevents fatal coronary heart disease events in high-risk, asymptomatic middle-aged men.