Asymptomatic type 2 diabetes mellitus was associated with a significantly higher prevalence of diastolic dysfunction compared to healthy controls (54.33% vs 11%, OR 2.18).
Case-Control (n=227)
Single-blind
No
Is the incidence of left ventricular diastolic dysfunction higher in asymptomatic patients with type 2 diabetes compared to healthy controls?
Asymptomatic patients with type 2 diabetes for over 5 years have a significantly higher incidence of left ventricular diastolic dysfunction compared to healthy controls, which correlates with disease duration, poor glycemic control, and microvascular complications.
Effect estimate: OR 2.18
Absolute Event Rate: 54.33% vs 11%
p-value: p=< 0.001
BACKGROUND: The incidence of heart failure in diabetic subjects is high even in the absence of hypertension and coronary artery disease. AIMS: The purpose of this study was to study the incidence of diastolic dysfunction in diabetic subjects and its relation to age, duration of diabetes mellitus (DM), Glycosylated hemoglobin (HbA1c) levels, obesity indices and diabetic microangiopathies. SETTINGS AND DESIGN: This was a case control prospective study conducted at the teaching hospital during a one year period. MATERIALS AND METHODS: A total of 127 subjects (case) with type 2 diabetes of more than five years duration were studied. Total 100 healthy subjects were included as the control group. Echocardiography was performed to assess left ventricular diastolic function. RESULTS: Out of the total 127 subjects, 69 (54.33%) from the case group had diastolic dysfunction, and 11% amongst 100 in the control group population showed the diastolic dysfunction (P 7.5% had a higher prevalence of diastolic dysfunction than subjects with HbA1c < 7.5% (P < 0.02). Diastolic dysfunction was present in majority of the subjects with autonomic neuropathy and retinopathy. CONCLUSIONS: Present study reveals high incidence of diastolic dysfunction in asymptomatic diabetic; subjects and, this finding was correlated with the duration of diabetes, HbA1c levels, obesity indices and diabetic microangiopathies. We conclude that early diagnosis and institution of treatment will reduce morbidity and improve the outcomes, and prevent future heart failure.
Patil et al. (Sat,) conducted a case-control in Asymptomatic type 2 diabetes mellitus with normal systolic function (n=227). Type 2 Diabetes Mellitus vs. Healthy age and sex matched controls was evaluated on Diastolic dysfunction (OR 2.18, p=< 0.001). Asymptomatic type 2 diabetes mellitus was associated with a significantly higher prevalence of diastolic dysfunction compared to healthy controls (54.33% vs 11%, OR 2.18).