Left ventricular diastolic dysfunction with preserved systolic function following acute MI was associated with higher 1-year cardiac mortality compared to preserved function (13% vs 2%, p<0.01).
Cohort (n=183)
Absolute Event Rate: 13% vs 2%
p-value: p=<0.01
The contribution of diastolic dysfunction in patients with preserved left ventricular (LV) systolic function to impaired functional status and cardiac mortality in myocardial infarction (MI) is unknown. In the present study, assessment of LV diastolic function was performed by Doppler analysis of the mitral and pulmonary venous flow, and the propagation velocity of early mitral flow by color M-mode Doppler echocardiography in 183 consecutive patients at day 5-7 following their first acute MI. Patients were classified into four groups: group A: preserved LV systolic and diastolic function (n = 73); group B: LV systolic dysfunction with preserved diastolic function (n = 10); group C: LV diastolic dysfunction with preserved systolic function (n = 60); group D: combined LV systolic and diastolic dysfunction (n = 40). The cardiac mortality rate at 1 year was significantly higher in groups C (13%) and D (38%) compared to A (2%) (p or=II (p = 0.006), and age (0.008) as predictors of cardiac death or readmission due to heart failure. The presence of LV diastolic dysfunction with preserved systolic dysfunction is associated with increased morbidity and mortality following acute MI.
Poulsen et al. (Mon,) conducted a cohort in Acute Myocardial Infarction (n=183). Left ventricular diastolic dysfunction with preserved systolic function vs. Preserved left ventricular systolic and diastolic function was evaluated on Cardiac mortality rate at 1 year (p=<0.01). Left ventricular diastolic dysfunction with preserved systolic function following acute MI was associated with higher 1-year cardiac mortality compared to preserved function (13% vs 2%, p<0.01).
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